Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics job opportunity at Novartis.

Home Jobs In Switzerland Tag: xRNA Therapeutics Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics position at Novartis


DatePosted 10 Days Ago bot
Novartis Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics
Experience: 3-years
Pattern: full-time
Country:
apply Apply Now
Salary:
Status:

xRNA Therapeutics

Copy Link Report
degreeOND
loacation Basel (City), Switzerland
loacation Basel (City)....Switzerland

Job Description Summary Location: Basel, Switzerland #onsite Role Purpose: Novartis xRNA Therapeutics is seeking a passionate and experienced PhD-level scientist to lead mid/large scale oligonucleotides synthesis and manage a team in Basel to support our xRNA Therapeutics development. This role requires extensive collaboration within a multidisciplinary environment, bridging research and development to enable the discovery and advancement of innovative siRNA therapies that address significant unmet medical needs.   Job Description Key Responsibilities Plan and execute medium- and large-scale solid-phase synthesis, purification, and analysis of chemically modified oligonucleotides and conjugates. Oversee a state-of-the-art oligonucleotide synthesis facility, including efficient management of capital and consumables budgets. Lead and mentor a team of scientists specializing in oligonucleotide synthesis, purification, analysis, and downstream processing at the millimole scale to support our growing siRNA portfolio. Ensure timely delivery of high-quality siRNA materials for in vitro screening and in vivo studies within drug candidate pipelines. Collaborate with discovery xRNA oligonucleotide synthesis teams in Basel and Cambridge. Provide technical leadership to the scale-up team, optimizing methodologies and processes for enhanced oligonucleotide synthesis efficiency. Partner with synthetic chemists and project teams to scale up new siRNA chemistries that address key scientific challenges and enable seamless progression into development. Document and clearly communicate scientific findings and insights to internal and external stakeholders through patent applications and scientific publications. Mentor, train, and support team members by sharing technical expertise and hands-on experience. Demonstrate strong problem‑solving skills and a solution-oriented mindset. Minimum Requirements - What you will bring to the role: Ph.D. in Chemistry with a focus on oligonucleotide synthesis, plus 2–3 years of industry experience. Proven track record in mid/large‑scale oligonucleotide solid‑phase synthesis using automated synthesizers, and downstream processing including expertise in process development. Demonstrated leadership capabilities and experience developing scientific teams. Ability to promote and implement innovative ideas within a global team environment. Strong independent problem-solving skills. Highly collaborative mindset. Ability to manage multiple priorities effectively while maintaining focus on key objectives. Excellent verbal and written communication skills. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message.   Skills Desired

Other Ai Matches

Manager - Forecasting Applicants are expected to have a solid experience in handling Job related tasks
Director, Therapeutic Area Medical Strategy Execution-RLT Applicants are expected to have a solid experience in handling Therapeutic Area Medical Strategy Execution-RLT related tasks
Senior Analyst - BSI Forecasting Applicants are expected to have a solid experience in handling Job related tasks
Principal Clinical Data Scientist Applicants are expected to have a solid experience in handling Job related tasks
Scientist - Analytical Science and Technology Applicants are expected to have a solid experience in handling Job related tasks
Technical Transfer Lead, Medical Device (m/f/d) Applicants are expected to have a solid experience in handling Medical Device (m/f/d) related tasks
Specialist MBR Designer Applicants are expected to have a solid experience in handling Job related tasks
Principal / Senior Principal Biostatistician Applicants are expected to have a solid experience in handling Job related tasks
Tehnolog proizvodnih procesov (m/ž/d) / Process Expert (m/f/d) Applicants are expected to have a solid experience in handling Job related tasks
Head, Quality Control Applicants are expected to have a solid experience in handling Quality Control related tasks
Quality Assurance Manager (LDC) Applicants are expected to have a solid experience in handling Job related tasks
Assoc. Dir. DDIT DEV CE Sol. Arch. Applicants are expected to have a solid experience in handling Job related tasks
Territory Business Executive-(Institutional Sales)-Chennai Applicants are expected to have a solid experience in handling Job related tasks
Lehre Chemieverfahrenstechnik (m/f/d) Applicants are expected to have a solid experience in handling Job related tasks
Info Specialist - Literature Intelligence Applicants are expected to have a solid experience in handling Job related tasks
remote-jobserver Remote
Associate Director, Field Launch Excellence Applicants are expected to have a solid experience in handling Field Launch Excellence related tasks
QA Officer Applicants are expected to have a solid experience in handling Job related tasks
Associate Director, Global Publications & Foundational Content Applicants are expected to have a solid experience in handling Global Publications & Foundational Content related tasks
Manager, Innovation Specialist, AI Applicants are expected to have a solid experience in handling Innovation Specialist, AI related tasks
Site Utility Lead Applicants are expected to have a solid experience in handling Job related tasks
VP, M&A Transactions Applicants are expected to have a solid experience in handling M&A Transactions related tasks
Value and Access Lead (Hanoi) Applicants are expected to have a solid experience in handling Job related tasks
Record to Report Sr. Specialist Applicants are expected to have a solid experience in handling Job related tasks