Post Doctorate Scientist job opportunity at Roche.

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DatePosted 11 Days Ago bot
Roche Post Doctorate Scientist
Experience: General
Pattern: full-time
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loacation Basel, Switzerland
loacation Basel....Switzerland

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position We are seeking a highly skilled and motivated Post Doctorate Scientist with expertise in next-generation sequencing (NGS) and molecular biology to join our dynamic research team. The ideal candidate will have a strong track record in developing and optimizing complex NGS workflows, protein biochemistry, and molecular assays, with a passion for translating experimental data into actionable insights. The opportunity Develop, prepare, and optimize complex NGS workflows, including protocols for Illumina platforms, particularly from low-input RNA samples, ensuring reproducibility and high data quality. Execute a broad range of molecular biology and biochemical techniques, including PCR, RT-qPCR, cloning, in vitro transcription, and western blotting. Perform protein expression, purification (e.g., affinity, ion exchange chromatography using systems like ÄKTA), and characterization to support experimental goals. Design, troubleshoot, and optimize experimental protocols to achieve high-quality results and meet project objectives. Conduct in vitro protein-nucleic acid interaction assays such as Bind-n-Seq, CLIP, SELEX, EMSA, or related techniques. Analyze NGS datasets using Python or R, applying bioinformatics skills and familiarity with machine learning concepts where appropriate. Collaborate effectively with cross-functional teams to design experiments, interpret results, and contribute to scientific publications. Who you are Ph.D. or equivalent experience in Molecular Biology, Biochemistry, Genetics, or a related field. Demonstrable expertise in NGS library preparation and workflow optimization with focus on protein-RNA interaction such as RIP-seq or CLIP-seq. Strong foundation in RNA biology focusing on RNA interference or antisense oligonucleotides (ASOs, miRNAs and siRNAs). Proficiency in general molecular biology techniques such as NGS, PCR, RT-qPCR and western blotting. Hands-on experience with cell culture and molecular biology methods. Demonstrated skills in designing and performing experiments in hypothesis-driven research, and in establishing innovative techniques.  Solid foundation in bioinformatics, with experience analyzing NGS data using Python or R; working knowledge of machine learning concepts is a plus. We are looking forward to your application!     Who we are A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together. Roche is an Equal Opportunity Employer.

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