Postdoctoral Research Associate - Biochemistry job opportunity at WashU.

Home Jobs In United States Of America Tag: Job Postdoctoral Research Associate - Biochemistry position at WashU


DatePosted 29 Days Ago bot
WashU Postdoctoral Research Associate - Biochemistry
Experience: General
Pattern: full-time
Country:
apply Apply Now
Salary:
Status:

Job

Copy Link Report
degreeOND
loacation Washington University Medical Campus, United States Of America
loacation Washington Uni..........United States Of America

Position Summary The Ghanbarpour Laboratory in the Department of Biochemistry and Molecular Biophysics at WashU Medicine is seeking a highly motivated Postdoctoral Researcher to join our interdisciplinary research program. Our lab investigates how bacteria and human mitochondria maintain homeostasis and respond to stress and environmental challenges. A central focus of our research is uncovering the molecular mechanisms of ATP-dependent AAA proteolytic machines, both soluble and membrane-spanning, and their accessory factors in bacterial and mitochondrial systems. We study how these complexes assemble, achieve substrate specificity, and promote bacterial recovery from antibiotic stress, environmental changes, and pathogen attack. These efforts combine cryo-EM and cryo-ET structural biology, biochemical and cellular assays, and mass spectrometry. The lab also explores bacterial defense mechanisms against bacteriophage infection, including rewiring of proteolytic systems and the deployment of innate immune strategies that enable survival during phage attack. In addition, another major focus of our research is protein engineering and the development of new molecular tools based on these proteolytic systems. Experience in cryo-EM/cryo-ET is highly desirable; additional expertise in biochemistry, genetic microbiology, or protein engineering is a plus. As a Postdoctoral Researcher, you will gain extensive hands-on training in cryo-EM sample preparation and data analysis, heterogeneity analysis tools, mass spectrometry, membrane biology, biochemistry, and cellular assays. The Ghanbarpour Laboratory and WashU Medicine provide state-of-the-art infrastructure for structural biology, biochemistry, and mass spectrometry, along with a highly collaborative research environment. Importantly, postdoctoral researchers are encouraged to dedicate up to 20% of their time to an independent research project, with the opportunity to develop a faculty-level research proposal. This position is well suited for individuals pursuing careers in academia and supported by NIH grant R35GM160328, the Longer Life Foundation, and WashU startup funds. Related papers: 1. Zhang T.; Barbosa R.; Ghanbarpour, A.; Laub, T. M.; Activation of a bacterial immunity protein via supramolecular assembly with multiple phage triggers, Nature (2026). 2. Iqbal, N.; Keller, S.; Ghanbarpour, A. Structural plasticity of the membrane-bound protein degradation assembly supports bacterial adaptation to stress. Biorxiv, 2025. 3. Ghanbarpour, A.; Telusma, B.; Powell, B.; Zhang, J. J.; Bolstad, I.; Vargas, C.; Keller, S.; Baker, T. A; Sauer, R. T; Davis, J. H.; An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins, The EMBO Journal, 44, 2501 (2025). 4. Ghanbarpour, A.; Sauer, R. T; Davis, J. H.; A proteolytic AAA+ machine poised to unfold a protein substrate, Nature Communications, 15, 9681 (2024). Job Description Primary Duties & Responsibilities: Information on being a postdoc at WashU in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/ . Trains under the supervision of a faculty mentor including (but not limited to): Assists with grant preparation and reporting. Prepares and submits papers on research. Assists in the design of research experiments. Evaluates research findings and assists in the reporting of the results. Conscientious discharge of their research responsibilities. Maintains conformity with ethical standards in research. Maintains compliance with good laboratory practice including the maintenance of adequate research records. Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications. Collegial conduct towards co-trainees, staff members and members of the research group. Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University. Working Conditions: This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals. Salary Range: Base pay is commensurate with experience. The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time. Required Qualifications Education: Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree. Certifications /Professional Licenses : No specific certification/professional license is required for this position. Work Experience: No specific work experience is required for this position. Skills: Not Applicable Driver's License: A driver's license is not required for this position. More About This Job At WashU, postdoctoral appointments: Have a 5-year term limit that includes previous experience.   Preferred Qualifications Education: No additional education unless stated elsewhere in the job posting. Certifications /Professional Licenses : No additional certification/professional licenses unless stated elsewhere in the job posting. Work Experience: No additional work experience unless stated elsewhere in the job posting. Skills: Collaboration, Data Analysis, Data Interpretations, Experimentation, Laboratory Operations, Laboratory Techniques, Researching, Results Reporting, Scientific Writing Questions For frequently asked questions about the application process, please refer to our External Applicant FAQ . Accommodation If you are unable to use our online application system and would like an accommodation, please email   CandidateQuestions@wustl.edu   or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits Statement Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits. EEO Statement Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. Washington University is dedicated to building a community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

Other Ai Matches

APP Fellowship - Psychiatry (Adult & Pediatrics) Applicants are expected to have a solid experience in handling Job related tasks
Postdoctoral Research Associate - Genetics Applicants are expected to have a solid experience in handling Job related tasks
Senior Research Technician - Cancer Center Biologic Therapy Core Facility Applicants are expected to have a solid experience in handling Job related tasks
Manager, Dining Operations - Dining Services and Business Operations Applicants are expected to have a solid experience in handling Dining Operations - Dining Services and Business Operations related tasks
Medical Assistant II - WUCA WU Care Applicants are expected to have a solid experience in handling Job related tasks
RN Clinical Nurse Coordinator - Oncology Applicants are expected to have a solid experience in handling Job related tasks
MRI Technologist - Radiology Applicants are expected to have a solid experience in handling Job related tasks
Clinical Research Coordinator I (Clinic) - Medical Oncology Applicants are expected to have a solid experience in handling Job related tasks
Research Technician I - Nutritional Science Applicants are expected to have a solid experience in handling Job related tasks
Physical Therapist/Clinical Associate (O'Fallon, MO) - Program in Physical Therapy (Orthopedics) Applicants are expected to have a solid experience in handling MO) - Program in Physical Therapy (Orthopedics) related tasks
Cage Wash Technician II - Comparative Medicine Applicants are expected to have a solid experience in handling Job related tasks
Bioinformatics Research Analyst - McDonnell Genome Institute Applicants are expected to have a solid experience in handling Job related tasks
Medical Assistant III (BJH West County) - Medical Oncology Applicants are expected to have a solid experience in handling Job related tasks
Medical Assistant III - Gastrointestinal Center Applicants are expected to have a solid experience in handling Job related tasks
Senior Research Administrator (Hybrid) - Pediatrics Applicants are expected to have a solid experience in handling Job related tasks
Vascular Lab Technologist (Sign-on Bonus) - Vascular Surgery Applicants are expected to have a solid experience in handling Job related tasks
Nurse Practitioner (ACNP) - Acute & Critical Care Surgery Applicants are expected to have a solid experience in handling Job related tasks
Research Assistant - Ob/Gyn Applicants are expected to have a solid experience in handling Job related tasks
Medical Secretary III - Surgery Applicants are expected to have a solid experience in handling Job related tasks
Nurse Practitioner (Oncology Research) - OBGYN Applicants are expected to have a solid experience in handling Job related tasks
Billing/Scheduling Associate II (Hybrid) - Orthopedic Surgery Applicants are expected to have a solid experience in handling Job related tasks
Research Opportunities - Neurology Applicants are expected to have a solid experience in handling Job related tasks
Medical Assistant III - Colon Rectal Surgery Applicants are expected to have a solid experience in handling Job related tasks